In "Exploit or Avoid," we take a close look at some of the week's more favorable — and tough — matchups for skill-position players. Here's who we like on each side of the ledger in Week 10:

Exploit

49ers WR Michael Crabtree (vs. St. Louis) — There's a lot to like about Crabtree this week. First, he comes off a spectacular game at Arizona (five catches, 72 yards, two TDs). The numbers are nice, but the film was even more flattering to Crabtree. He looked like a legitimate difference-making receiver in the 49ers' Week Eight win, getting the best of talented Cardinals CB Patrick Peterson. Making Crabtree even more appealing: he lit up the Rams for 12 catches, 182 yards and three TDs (15 targets) in two 2011 matchups. Yes, the St. Louis secondary is better than a season ago, but the Rams nonetheless had no real answers for the Patriots two weeks ago. Crabtree is playing too well to sit.

Bills TE Scott Chandler (at New England) — In the first 2012 meeting with the Patriots, Chandler was targeted a season-high eight times. And did he ever do well with those opportunities, catching a pair of TD passes and racking up 62 yards on four receptions. While Chandler hasn't caught a TD since, he did rack up 51 receiving yards on three catches at Houston in Week 10. He's an intriguing Week 10 play.