By GREG BEACHAM, AP Sports Writer

SAN FRANCISCO (AP) — Kevin Kolb passed for 253 yards while capably filling in for injured Michael Vick, and Quintin Mikell returned Alex Smith's fumble 51 yards for a touchdown early in the fourth quarter of the Philadelphia Eagles' 27-24 victory over the winless San Francisco 49ers on Sunday night.

LeSean McCoy rushed for a score and Trevard Lindley made a last-minute interception for the Eagles (3-2), who forced five turnovers and survived San Francisco's late rally for their fifth straight win over the 49ers (0-5).

Smith passed for 309 yards, but also committed three turnovers. He received thunderous boos from the Candlestick Park crowd and an apparent tongue-lashing from coach Mike Singletary before leading two fourth-quarter TD drives.

After throwing TD passes to Vernon Davis and Frank Gore, Smith got the 49ers past midfield again in the final minute, but he was hit by Trevor Laws while making a throw. Lindley intercepted the wobbling pass with 28 seconds to play, and the 49ers dropped to their worst start in 31 years.

Kolb made his fourth career start in place of Vick, who injured his ribs in last week's loss to Washington. Kolb was the Eagles' starting quarterback out of training camp, but sat out with a concussion after the opener while Vick was chosen the NFC's offensive player of the month for September.

The 49ers sacked Kolb four times, but he capably managed the offense during a 21-for-31 performance, hitting tight end Brent Celek for an early score. Kolb also showed off some surprisingly fleet feet with a 19-yard run on a third-and-18 play in the third quarter, dodging between tacklers and ball-faking with a slickness that recalled Vick at his elusive best.